Kispersky, Tilman J, Economo, Michael N, Randeria, Pratik, White, John A. GenNet: A Platform for Hybrid Network Experiments. Front Neuroinform (2011) vol. 5 pp. 11. We describe General Network (GenNet), a software plugin for the real time experimental interface (RTXI) dynamic clamp system that allows for straightforward and flexible implementation of hybrid network experiments. This [...]

Stigen, Tyler, Per Danzl, Jeff Moehlis, and Theoden Netoff. Controlling Spike Timing and Synchrony in Oscillatory Neurons. J Neurophysiol (2011) pp. We describe an algorithm to control synchrony between two periodically firing neurons. The control scheme operates in real-time using a dynamic clamp platform. This algorithm is a low impact stimulation method that brings the [...]

Lobb and Paladini. Application of a NMDA Receptor Conductance in Rat Midbrain Dopaminergic Neurons Using the Dynamic Clamp Technique. J Vis Exp (2010) (46) Neuroscientists study the function of the brain by investigating how neurons in the brain communicate. Many investigators look at changes in the electrical activity of one or more neurons in response [...]

O Miranda-Domínguez, J Gonia and T I Netoff. Firing rate control of a neuron using a linear proportional-integral controller. J. Neural Eng. (2010) Vol. 7 No. 6. Some electrophysiology experiments require periodically firing neurons. One example is when measuring a neuron’s phase response curve (PRC) where a neuron is stimulated with a synaptic input and [...]

Lin RJ, Bettencourt J, Wha Ite J, Christini DJ, Butera RJ. Real-time Experiment Interface for biological control applications. Conf Proc IEEE Eng Med Biol Soc (2010) vol. 1 pp. 4160-3 The Real-time Experiment Interface (RTXI) is a fast and versatile real-time biological experimentation system based on Real-Time Linux. RTXI is open source and free, can [...]

Sieling, Fred H., Canavier, Carmen C, Prinz, Astrid A. Inclusion of noise in iterated firing time maps based on the phase response curve. Phys Rev E (2010) vol. 81 (6 Pt 1) pp. 061923. The infinitesimal phase response curve (PRC) of a neural oscillator to a weak input is a powerful predictor of network dynamics; [...]

Lobb et al. A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons. J Neurophysiol (2010) vol. 104 (1) pp. 403-13 Dopaminergic neurons are subject to a significant background GABAergic input in vivo. The presence of this GABAergic background might be expected to inhibit dopaminergic neuron firing. However, dopaminergic neurons are [...]

Otte S, Hasenstaub A, Callaway EM. Cell Type-Specific Control of Neuronal Responsiveness by Gamma-Band Oscillatory Inhibition (2010) J Neurosci, 30 (6): 2150-2159. Neocortical networks are composed of diverse populations of cells that differ in their chemical content, electrophysiological characteristics, and connectivity. Gamma-frequency oscillatory activity of inhibitory subnetworks has been hypothesized to regulate information processing in [...]

Fernandez FR, White JA. Gain Control in CA1 Pyramidal Cells Using Changes in Somatic Conductance (2010) J Neurosci, 30 (1): 230-241. Gain modulation is an important feature of neural activity. Previous work has focused on the ability of background synaptic noise to modulate the slope (i.e., gain) of the frequency–current (f–I) relationship in neurons. To [...]

Deister CA, Teagarden MA, Wilson CJ, Paladini, CA. An Intrinsic Neuronal Oscillator Underlies Dopaminergic Neuron Bursting (2009) J Neurosci, 29 (50):15888-15897. Dopaminergic neurons of the ventral midbrain fire high-frequency bursts when animals are presented with unexpected rewards, or stimuli that predict reward. To identify the afferents that can initiate bursting and establish therapeutic strategies for [...]