Mike Skocik and Alexay Kozhevnikov., “Real-time system for studies of the effects of acoustic feedback on animal vocalizations.,” Frontiers in Neural Circuits. 2013 Jan 7;6. Studies of behavioral and neural responses to distorted auditory feedback (DAF) can help shed light on the neural mechanisms of animal vocalizations. We describe an … more
Broicher T, Malerba P, Dorval AD, Borisyuk A, Fernandez FR, White JA., “Spike Phase Locking in CA1 Pyramidal Neurons Depends on Background Conductance and Firing Rate.,” J Neurosci. 2012 Oct 10;32(41):14374-88. Oscillatory activity in neuronal networks correlates with different behavioral states throughout the nervous system, and the frequency-response characteristics of … more
Ted Brookings, Rachel Grashow and Eve Marder, “Statistics of neuronal identification with open- and closed-loop measures of intrinsic excitability,” Frontiers in Neural Circuits, vol. 6, no. 19. 2012. In complex nervous systems patterns of neuronal activity and measures of intrinsic neuronal excitability are often used as criteria for identifying and/or … more
M. N. Economo and J. A. White, “Membrane Properties and the Balance between Excitation and Inhibition Control Gamma-Frequency Oscillations Arising from Feedback Inhibition.,” PLoS Comput Biol, vol. 8, no. 1, p. e1002354, Jan. 2012. Computational studies as well as in vivo and in vitro results have shown that many cortical … more
S. Wang, L. Chandrasekaran, F. R. Fernandez, J. A. White, and C. C. Canavier, “Short Conduction Delays Cause Inhibition Rather than Excitation to Favor Synchrony in Hybrid Neuronal Networks of the Entorhinal Cortex,” PLoS Comput Biol, vol. 8, no. 1, p. e1002306, Jan. 2012. How stable synchrony in neuronal networks … more
E. Idoux and J. Mertz, “Control of local intracellular calcium concentration with dynamic-clamp controlled 2-photon uncaging.,” PLoS One, vol. 6, no. 12, p. e28685, 2011. The variations of the intracellular concentration of calcium ion ([Ca(2+)](i)) are at the heart of intracellular signaling, and their imaging is therefore of enormous interest. … more
R. V. Madhvani, Y. Xie, A. Pantazis, A. Garfinkel, Z. Qu, J. N. Weiss, and R. Olcese, “Shaping a New Ca2+ Conductance to Suppress Early Afterdepolarizations in Cardiac Myocytes.,” J Physiol (Lond), Oct. 2011. Sudden cardiac death (SCD) due to ventricular fibrillation (VF) is a major world-wide health problem. Common … more
Kispersky, Tilman J, Economo, Michael N, Randeria, Pratik, White, John A. GenNet: A Platform for Hybrid Network Experiments. Front Neuroinform (2011) vol. 5 pp. 11. We describe General Network (GenNet), a software plugin for the real time experimental interface (RTXI) dynamic clamp system that allows for straightforward and flexible implementation … more
C. Iglesias, C. Meunier, M. Manuel, Y. Timofeeva, N. Delestrée, and D. Zytnicki, “Mixed mode oscillations in mouse spinal motoneurons arise from a low excitability state,” J Neurosci, vol. 31, no. 15, pp. 5829–5840, Apr. 2011. We explain the mechanism that elicits the mixed mode oscillations (MMOs) and the subprimary … more
C. J. Lobb, C. J. Wilson, and C. A. Paladini, “High Frequency, Short Latency Disinhibition Bursting of Midbrain Dopaminergic Neurons,” J Neurophysiol, Mar. 2011. During reinforcement and sequence learning, dopaminergic neurons fire bursts of action potentials. Dopaminergic neurons in vivo receive strong background excitatory and inhibitory inputs, suggesting that one … more