Requirements: none Limitations: none noted   This module contains a spike detector based on a positive threshold crossing (see SpikeDetect module). It computes the average ISI and the current coefficient of variation. These values are continuously updated with each spike until the statistics are reset with the button. Input Channels input(0) – “Vm” : Membrane [...]

Requirements: Spike Detector Limitations: none noted   This module controls the Intespike interval (ISI) of a neuron using a Proportional Integral controller. The model automatically tunes the PI controller parameters to the neuron. The goal of the PI controller is to make small changes in current at each action potential onset to maintain the neuron [...]

Requirements: none Limitations: Generator class (included)   This module implements a protocol for performing conduction block experiments on nerve fibers using high frequency AC current (HFAC) stimuli. Action potentials in the nerve are evoked with a single biphase square pulse and the HFAC signal is a sinusoidal waveform. You have an option to select which [...]

Requirements: All required components included. Limitations: None noted. Authors: Tilman Kispersky*, Michael Economo*, Pratik Randeria, John A. White     This plugin implements a framework for Hybrid Network experiments. Hybrid networks entail the coupling of biological circuit elements with simulated ones. Hybrid Network experiments have been historically hindered by the difficulty of implementing the network. [...]

Requirements: none Limitations: none noted   This module reciprocally couples two neurons with alpha synapses. It requires the membrane potential of both cells and the inputs from two spike detector modules (eg. Spike Detect). It outputs the two synaptic currents which must then be appropriately connected. This module can be used to couple two biological [...]

Requirements: none Limitations: none noted   This module creates an artificial synapse where the fixed conductance change is described by an alpha function. The fixed conductance waveform is pre-computed according to: (1)   The current is computed according to Ohm’s Law: (2)   This conductance is triggered by an event indicated by a value of [...]

Requirements: none Limitations: none noted   This module applies an alpha-shaped conductance to the cell at a fixed delay after 10 interspike intervals (ISI). It computes an intrinsic period P0 by averaging the most recent 5 of 10 ISIs. Thus, the value of P0 can change over time. The period after the perturbed period is [...]

Requirements: none Limitations: none noted   This plugin allows you to deliver a series of current step commands. Output Channels output(0) – “Iout” : Step current command in amperes. Connect to the amplifer external signal input. Parameters Period (s): period of step input Delay (s): delay between step commands Min Amp (pA): minimum amplitude Max [...]

Requirements: GMP library (included in Live CD) Limitations: none noted   This is a collection of models built using the DYNAMO scripting language. See the DYNAMO tutorial for a quick introduction on how they work. These can be compiled using the DYNAMO Model Loader in RTXI. The result is a module based on the DefaultGUIModel [...]